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#595: The Estrobolome Explained: How Your Gut Shapes Your Hormones

#595: The Estrobolome Explained: How Your Gut Shapes Your Hormones

December 23, 2025 By Jared St. Clair

On this episode of Vitality Radio, Jared welcomes functional medicine dietitian and gut-health expert Lisa Smith for a deep dive into one of the most overlooked systems influencing hormone balance: the estrobolome. If you’ve never heard that word before, you’re not alone — but by the end of this conversation you’ll understand why the estrobolome may be the missing link in stubborn hormone symptoms, estrogen dominance, thyroid sluggishness, mood changes, and even men’s testosterone challenges. Jared and Lisa break down how gut bacteria influence estrogen detoxification, what beta-glucuronidase is actually doing behind the scenes, why bile flow matters (especially if you don’t have a gallbladder), and how fiber, cruciferous vegetables, and targeted nutrients can support healthy hormone metabolism. This is a practical, empowering discussion designed to help you understand root causes rather than chase symptoms. Whether you’re navigating perimenopause, PCOS, thyroid issues, mood swings, stubborn weight, or low energy, this episode brings science down to earth with simple, realistic starting points for rebuilding gut balance and restoring hormonal resiliency — naturally and safely.

Products:

Precision Probiotic

LiverVitality 

EndoCleanse

Additional Information:

Pretty Well Podcast

Instagram

Lisa Smith Wellness

Listen on your favorite podcast app including Apple or Spotify!

You can follow us on Instagram @vitalitynutritionbountiful and @vitalityradio, or on Facebook  and Twitter. Check us out online at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcast.

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